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KMID : 0984919990010010047
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Journal of Skin Barrier Research
1999 Volume.1 No. 1 p.47 ~ p.51
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The Skin Responses to Dimethyl Sulforide in Atopic Dermatitis Patients
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Kim Gyeong-Il
Lee Ji-Young
Park Cheon-Wook
Lee Cheol-Heon
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Abstract
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Dimethyl suloxide(DMSO) acts as an urticariogenic agent and a primary irritant. A DMSO skin test which measures responses in skin after exposure for 5 minutes could be a simple and easy method in evaluating cutaneous irritation. Generally, atopic dermatitis patients tend to be susceptivle to various irritants and have a defect in the cutaneous barrier fucction, In our study, we used DMSO concentrations of 90%, 95% and 100%, and evaluated the skin responses using measures such as visual scores(wheals), transepidermal water loss(TEWL), and erythema index(E-index) after DMSO skin test in the forearm skin of atopic dermatits patients and normal healthy controls.
The result include visual socres recorded as means of 0.50, 1.40 and 3.50 with 90%, 95% and 100% DMSO concentration in normal controls, respectively. In atopic dermatitis patients, 0.17, 0.71 and 2.18 with each concentration in normal appearing
area, and 0.71, 1.71 and 3.29 with each concantration in lesional area were recorded, respectively. The TEML values increased as DMSO concentration increased, and the TEWL values of the lesional area in atopic dermatiltis patients were higher than both baseline and postirritation TEWL values of normal controls and normally appearing areas of atopic dermatitis patients. The baseling E-index was higher in the lesional area of atopic dermatitis patients than in normal control and in normal apperaing areas of atopic dermatitis patients, but the postirritating E-index was significantly increased only in normal controls. In conclusion, visual scores in normal looking areas of atopic dermatitis patients were lower than in other areas. Postirriation TEWL values were significantly increased in all cases, and both baseline and postirriation TEWL values in lesional areas of atopic dermatitis patients were even higher than in normal control and in normal looking areas of atopic dermatitis patients. There were no differences in basesline E-index between normal controls and normal looking areas of atopic dermatitis patients, but a significantly increased E-index was noted in lesionsl areas of atopic dermatitis patients. There was increased postirritation E-index only in normal controls.
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KEYWORD
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Dimethyl sulfoxide(DMSO), atopic dermatitis, barrier function
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